â  dukespace investigation of the molecular mechanism for cerebral cavernous malformations dukespace login dukespace home → electronic theses and dissertations → duke dissertations → view item javascript is disabled for your browser. Some features of this site may not work without it. Investigation of the molecular mechanism for cerebral cavernous malformations akers, amy lee uri: date: 2009 abstract:

cerebral cavernous malformations (ccm) are vascular anomalies of the central nervous system comprised of grossly-dilated blood-filled capillaries. Ccm leisons may occur sporadically or by inheritance of a mutation in one of three genes, ccm1, ccm2, or ccm3. Prior to the identification of the genes involved in pathogenesis, sporadic and inherited cases could be distinguished by lesion burden where sporadic cases exclusively showed single lesions, and patients with inherited disease developed multiple lesions. This observation lead us to hypothesize that ccm lesion genesis may follow a two-hit genetic mechanism. viagra online http://medicaresupplementspecialists.com/pfz-cheap-viagra-no-prescription-sy/ generic viagra online buy viagra online howtosmudge.com/pjn-generic-viagra-canadian-online-ke/ buy viagra online viagra without a doctor prescription buy viagra online cheap viagra cheap generic viagra To investigate this hypothesis and determine the molecular mechanism underlying ccm pathogeneis, we used resected human lesion samples to identify biallelic somatic and germline mutations that are specific to the lesion endothelium. Additionaly, we created mouse models in which heterozygosity of ccm1 or ccm2 in conjunction with deficiency for either the p53 or msh2 genes, recapitulates the genetic and phenotypic properties of the human condition. In conclusion, we have provided evidence that ccm lesion genesis requires inactivation of both allelic copies for ccm1, ccm2, or ccm3within a subset of vascular endothelium.

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Jankola Library and Slovak Museum exists to promote and preserve Slovak intellectual and cultural life by providing books and reading material and exhibiting artificats memorabilia that pertain to Slovak and Slavic history, language, literature, fine arts, spirituality and science for all people who honor and cherish the faith and heritage of their ancestors.


The Jankola Library and Slovak Museum, a unique and specialized  source of information, is maintained and supported by the Congregation of the Sisters of Saints Cyril and Methodius, a religious congregation established in 1909 by Father Matthew Jankola (1872-1916), an immigrant priest from Slovakia.  Since Father Jankola’s first purpose for founding a religious congregation of teachers was to promote and preserve Slovak faith and culture, the Sisters chose to name the Library in  his memory.

The history of this prestigious center began in the mid-1940’s when collections of books, papers, and artifacts pertaining to Slovak history, poetry, and literature were arbitrarily being sent to the Sisters.  Over the years the materials  accumulated from all over the world. In 1968  Sister M. Martina Tybor, SS.C.M., an outstanding scholar, teacher, poet, translator, and author catalogued these valuable materials and laid the foundation for what has become Jankola Library.

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Grants from the four Slovak Catholic Fraternal Societies, namely, First Catholic Slovak Union (Jednota); First Catholic Slovak Ladies’ Association;  Ladies’ Pennsylvania Slovak Catholic Union; and Slovak Catholic Sokol provide an invaluable source of income to sustain the life of Jankola Library.   Individual donations, corporate contributions, bequests, and memorials are also gratefully accepted to help keep the Library relevant  for interested researchers.

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Sister M. Mercedes Voytko, SS.C.M. succeeded Sister M. Martina Tybor as Director of the Jankola Library (1992-2007).  One of her major accomplishments was the organization of the valuable artifacts which had been donated to the Library.  With the generous and dedicated assistance of Sister Mercedes’ sister, Ms. Catherine Voytko,  they properly categorized  and artistically exhibited many treasured items.  Assisting with this daunting and time-consuming task, the members of The Northeast Pennsylvania Slovak Heritage Society  volunteered  their time, talent, and energy to fulfill  the mission of  Jankola Library and Slovak Museum.

In September, 2007, Sister M. John Vianney Vranak, SS.C.M. accepted the responsibility as Director of the Jankola Library and Slovak Museum.  Building on the foundation laid by her predecessors, she hopes to broaden the services of the Library and Museum so that scholars, researchers and visitors, would benefit from the valuable materials preserved in Jankola Library and Slovak Museum.

Sister M. John Vianney Vranak, SS.C.M. completed her tenure as Director of Jankola Library and Slovak Museum in 2010. The Congregation of the Sisters of Saints Cyril and Methodius endorsed Sister M. Catherine Laboure Bresnock, SS.C.M. as Director of Jankola Library and Slovak Museum and Sister Loretta Marie Hrubec, SS.C.M. as Librarian to continue the mission of the library and museum which is to preserve and promote the history, heritage, culture and traditions of our faith-filled Slovak ancestors as well as to provide the necessary resources for research scholars.


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